Best of Twitter - Week of September 14, 2020
Boys born in December (i.e., the youngest in class) ~50% more likely to have ADHD diagnosis compared to boys born in January. Difference is even more marked for girls (~100% more likely). Data from Norwegian nationwide cohort study: doi.org/10.1177%2F1403…
"Murder rates would be up to five times higher than they are but for medical developments over the past 40 years...Without this technology, there would be no less than 50,000 and as many as 115,000 homicides annually instead of an actual 15,000 to 20,000" ncbi.nlm.nih.gov/pmc/articles/P…
Ever wonder what transgenerational epigenetic inheritance (TEI) is good for? (Yes, what’s the #PhysiologicalRelevance?) We showed earlier that worms can learn to avoid pathogens, and use TEI to pass on this memory for a few generations. In our new paper....
I have nearly given myself caffeine poisoning with this strategy, so I recommend maybe not making it literally coffee, but FWIW back in better times this was very much an important part of integrating as a remote employee.
(My actual record was 37 in a week.)
Christopher Orr @orrc
Brings me back to winter 2019 - when @RoamResearch had less than 5k in the bank and no leads on investors.
@NotionHQ was famously turning $$$ away, so gave @ivanhzhao a demo, offered to share our research if he would invest or help us raise.
"We have enough ideas" he said...
Notion @NotionHQ
^ the number of people in quote-tweets and replies who have a similar experience is remarkable
Under-offered writing advice: be funny!
Most of my favorite writers are *way* funnier than me. Poeple gravitate more towards "fun to read" (vs e.g. "insightful") than we realize or admit!
Also, it's easier to make more jokes than to have better insights :)
Two days ago I almost drowned in a sensory deprivation flotation tank when my hair was sucked into the filtration system. I wasn’t told about much of the actual float procedure nor an emergency button. No one meant to check in on me.
Starting to think "running away from your pain" is underrated. Had some emotional pain recently that I distracted myself from through games and social media. Apparently that allowed it to be processed in the background, as it eventually transformed into a pleasant warmth.
@PeterKolchinsky 🏆
Malignant by @VPrasadMDMPH
Topic 🦀🏥
Blew my mind re. how cancer drugs get approved. Hint: it's a mess.
• Surrogate endpoints (eg tumor shrinks) over(ab)used
• Control arms not always std of care, esp post-protocol
• Economics = Ph3 after failed Ph2 can have positive💲EV
+
Jaw-dropping: the fact that so many cancer drugs are approved by the FDA without little to no evidence that they improve lifespan or quality of life (instead, they improve artificial and easy-to-rig measures like time-during-which-tumor-shrinkage is over an arbitrary percentage).
I suspect founding stories deter innovation. A coherent founding narrative can only be told after-the-fact, and is often simplified to sound linear. In the moment, when following instinct, I don't really know why I'm doing something, and the path is certainly not linear. 1/2
Woah. TIL...@apoorva_mehta (Founder & CEO of @Instacart) successfully convinced YCombinator to let him join the YC S12 batch two months after the application deadline.
techcrunch.com/2012/08/18/how…
A reader wrote a rebuttal to the last week’s tweet on market in capability to go to the moon: https://applieddivinitystudies.com/2020/09/17/markets-nasa/. Have a great week!