Best of Twitter - Week of May 23, 2022

Aran Komatsuzaki @arankomatsuzaki

Large Language Models are Zero-Shot Reasoners Simply adding “Let’s think step by step” before each answer increases the accuracy on MultiArith from 17.7% to 78.7% and GSM8K from 10.4% to 40.7% with GPT-3. arxiv.org/abs/2205.11916

Chan Kha Vu 🇺🇦🌻🚜 @chankhavu

@0xmaddie_ @arankomatsuzaki Future math proof sketches generation be like: "Prove X. Chanelling inner Ramanujan", "Compute Y the way Terry Tao would do", "what thoughts would Grothendieck have on this?"

Benjamin Hilton @benjamin_hilton

12. "Teddy bears swimming at the Olympics 400m Butterfly event." (L: Imagen, R: DALL-E)

Myles Danielsen @MylesDanielsen

Pretty wild how wrong economists and the Fed were a year ago (or even in Oct)

Dr. Brandon Berry @mitobrandon

❗Light-activated mitochondria extend lifespan in C. elegans. This project has been a long time coming, I'm so excited to share 🧵👇 biorxiv.org/content/10.110…

biorxiv.orgOptogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespanDespite longstanding scientific interest in the centrality of mitochondria to biological aging, directly controlling mitochondrial function to test causality has eluded researchers. We show that specifically boosting mitochondrial membrane potential through a light-activated proton pump reversed age…

DeepMind @DeepMind

Gato🐈a scalable generalist agent that uses a single transformer with exactly the same weights to play Atari, follow text instructions, caption images, chat with people, control a real robot arm, and more: dpmd.ai/Gato Paper: dpmd.ai/Gato-paper 1/

Vladimir Seplyarskiy @seplyarskiy

Indeed great collaboration. We found that ppl diagnosed with schizophrenia have 50-fold increased rate of T>G and CpG transversions in TFBS in early development. biorxiv.org/content/10.110…

Eduardo Maury @emauryg

Glad to share the latest preprint from my PhD w/ my co-first authors @jones_attila @seplyarskiy! We find enrichment of somatic variants at transcription factor binding sites in schizophrenia w/ specific mutational patterns. In collaboration w/@ChrisAWalsh1 @AndyChessNYC labs🧵1/n https://t.co/DCLQHwr6rU

Shivan Kaul Sahib @shivan_kaul

This is shocking. DuckDuckGo has a search deal with Microsoft which prevents them from blocking MS trackers. And they can't talk about it! This is why privacy products that are beholden to giant corporations can never deliver true privacy; the business model just doesn't work.

Gavin Hales @gmhales

@talkRADIO Should we ban motorbikes? assets.publishing.service.gov.uk/government/upl…

^ note that first and second columns are “walking” and “cycling”

Quarantined section

Paul Bleicher @pbleic

1/Paxlovid rebound: with 2/2 in my family with Paxlovid rebound, stories rife on Twitter, and 2 completely unscientific polls showing 46-47% rebound, I am thinking about Paxlovid efficacy in terms of relative risk, absolute risk, and Number Needed to Treat (NNT)

Adam W Gaffney @awgaffney

An important new study is out. Baseline findings from the NIH's longitudinal, intramural Long COVID study — perhaps the most detailed, controlled, comprehensive investigation of multiple health metrics in this setting thus far conducted — were just published in @AnnalsIM A🧵 1/

Adam W Gaffney @awgaffney

The study enrolled 189 mostly non-hospitalized adults post-Covid & 120 controls. Post-acute sequelae of COVID (PASC) were defined as subgroup w/ worsening symptoms/conditions after COVID-19 All participants went to the NIH for an extensive battery of tests, including: 2/

Adam W Gaffney @awgaffney

To summarize, there was a large burden of symptoms & worse mental health post-COVID (particularly among those with PASC) but no difference in objective neurocognition, & no evidence of "ongoing systemic inflammation or immune activation" or any organ damage. Some caveats: 13/

Nathan Taylor @ntaylor963

interesting and I think balanced post by Derek Lowe on long covid study "See, I told you this was going to be controversial! ....so far there are no diagnostic findings that would allow you to even say for sure that post-Covid even exists, biochemically." science.org/content/blog-p…